Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Transthyretin (TTR) is a tetrameric transport protein highly conserved through vertebrate
evolution and synthesized in the liver, choroid plexus, and retinal pigment epithelium. TTR …

Since the identification of a valine-to-isoleucine substitution at position 122 (TTR V122I;
pV142I) in the transthyretin (TTR)-derived fibrils extracted from the heart of a patient with late …

The function of the cerebrospinal fluid (CSF) and the tissue that secretes it, the choroid
plexus (CP), has traditionally been thought of as both providing physical protection to the …

Transmission and secretion of signals via the choroid plexus (ChP) brain barrier can
modulate brain states via regulation of cerebrospinal fluid (CSF) composition. Here, we …

Cells that have evolved to produce large quantities of secreted proteins to serve the
integrated functions of complex multicellular organisms are equipped to compensate for …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Abstract Transthyretin (TTR)(formerly, thyroxine binding prealbumin) is an evolutionarily
conserved serum and cerebrospinal fluid protein that transports holo-retinol-binding protein …

Mutations in transthyretin (TTR) are associated with familial amyloid polyneuropathy, a
neurodegenerative disorder characterized by TTR deposition in the PNS. The aim of this …

A cardinal pathological lesion of Alzheimer's disease (AD) is the deposition of amyloid β
(Aβ) in the brain. We previously reported that exposing transgenic mice harboring …