Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important
functions in the regulation of growth and survival of certain cell types during embryonal …

Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Glioblastoma progression in its early stages remains poorly understood. Here, we transfer
PDGFB and genetic barcodes in mouse brain to initiate gliomagenesis and enable direct …

Throughout the vertebrate evolution, Sox2 marks the developing nervous system from its
earliest developmental stages and, therein, the most undifferentiated precursor cells …

Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain
tumor and its prognosis is universaly fatal. No significant improvement has been made in …

The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in
normal embryonic development, cellular differentiation, and response to tissue damage. Not …

The stem cell–determining transcription factor Sox2 is required for the maintenance of
normal neural stem cells. In this study, we investigated the requirement for Sox2 in neural …

SOX genes are developmental regulators with functions in the instruction of cell fate and
maintenance of progenitor's identity during embryogenesis. They play additional roles …

Signal transducer and activator of transcription (STAT) 3 has been described as a “master
regulator” of signaling pathways involved in the transition from low-grade glioma (LGG) to …

Platelet-derived growth factor receptor-beta (PDGFRβ) is a receptor tyrosine kinase found in
cells of mesenchymal origin such as fibroblasts and pericytes. Activation of this receptor is …