Mitochondria has an essential role in myocardial tissue homeostasis; thus deterioration in
mitochondrial function eventually leads to cardiomyocyte and endothelial cell death and …

Transforming growth factor-β (TGF-β) is a common mediator of cancer progression and
fibrosis. Fibrosis can be a significant pathology in multiple organs, including the heart. In this …

Alcohol abuse; the most common and costly form of drug abuse, is a major contributing
factor to many disease categories. The alcohol-attributable disease burden is closely related …

Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue
proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of …

The consumption of ethanol can have both beneficial and detrimental effects on the function
of the heart and cardiovascular system, depending on the amount consumed. Low‐to …

Matrix metalloproteinases (MMPs) are a family of zinc dependent endopeptidases whose
main function is to degrade and deposit structural proteins within the extracellular matrix …

Shikonin, isolated from the roots of herbal plant Lithospermum erythrorhizon, is a
naphthoquinone. It has been reported to exert beneficial anti-inflammatory effects and anti …

The present study aimed to determine the role and regulatory mechanism of hydrogen
sulfide (H 2 S) in the amelioration of doxorubicin‑induced myocardial fibrosis in rats. It is …

Polydatin has attracted much attention as a potential cardioprotective agent against
ischemic heart disease and diabetic cardiomyopathy. However, the effect and mechanism of …

Synaptic plasticity has long been known to involve three key elements of neuropil, the
presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular …