[PDF][PDF] Biliary atresia in children: update on disease mechanism, therapies, and patient outcomes

S Antala, SA Taylor - Clinics in liver disease, 2022 - Elsevier
Biliary atresia is a rare disease but remains the most common indication for pediatric liver
transplantation as there are no effective medical therapies to slow progression after …

Genetic contributions to biliary atresia: A developmental cholangiopathy

DJ Hellen, SJ Karpen - Seminars in liver disease, 2023 - thieme-connect.com
Biliary atresia (BA) is the most prevalent serious liver disease of infancy and childhood, and
the principal indication for liver transplantation in pediatrics. BA is best considered as an …

Serum FGF19 predicts outcomes of Kasai portoenterostomy in biliary atresia

I Nyholm, M Hukkinen, M Pihlajoki, JR Davidson… - Hepatology, 2023 - journals.lww.com
Serum FGF19 predicts outcomes of Kasai portoenterostomy in b... : Hepatology Serum FGF19
predicts outcomes of Kasai portoenterostomy in biliary atresia : Hepatology AASLD Publications …

Development of liver inflammatory injury in biliary atresia: from basic to clinical research

S Chusilp, F Balsamo, B Li, P Vejchapipat… - Pediatric Surgery …, 2023 - Springer
Biliary atresia (BA) is a severe cholangiopathy in infants. It is characterized by inflammatory
fibro-obliteration of the intra-and extrahepatic bile ducts. Although the restoration of bile flow …

Liver secretin receptor predicts portoenterostomy outcomes and liver injury in biliary atresia

N Godbole, I Nyholm, M Hukkinen, JR Davidson… - Scientific Reports, 2022 - nature.com
Biliary atresia (BA) is a chronic neonatal cholangiopathy characterized by fibroinflammatory
bile duct damage. Reliable biomarkers for predicting native liver survival (NLS) following …

Duration from the first pale stool to portoenterostomy is prognostic in biliary atresia. Comparison with age at portoenterostomy

H Nakamura, M Ara, H Koga, G Miyano… - Clinics and Research in …, 2021 - Elsevier
Objective Three criteria (age at first pale stool, age at portoenterostomy, and duration from
the first pale stool to portoenterostomy) were assessed for prognostic value in biliary atresia …

A novel model for predicting the clearance of jaundice in patients with biliary atresia after kasai procedure

Y Zhang, Q Wang, S Pu, J Wang, B Xiang, J Liu… - Frontiers in …, 2022 - frontiersin.org
Background The failed clearance of jaundice (CJ) in patients with biliary atresia (BA) after
the Kasai procedure (KP) often leads to a shorter native liver survival (NLS) time and earlier …

Characteristics of SOX9-positive progenitor-like cells during cholestatic liver regeneration in biliary atresia

Y Lin, F Zhang, L Zhang, L Chen, S Zheng - Stem Cell Research & …, 2022 - Springer
Abstract Background The progression of Biliary Atresia (BA) is associated with the number of
reactive ductular cells (RDCs) whose heterogeneity in origin and evolution in humans …

SOX9 contributes to the progression of ductular reaction for the protection from chronic liver injury

D Yoshii, K Shimata, Y Yokouchi, Y Komohara, H Suda… - Human Cell, 2022 - Springer
The transcription factor sex-determining region Y-box 9 (SOX9) is a biliary epithelial marker
ectopically expressed in hepatocytes (SOX9+ hepatocytes). SOX9+ hepatocytes are …

Overexpression of ring finger protein 20 inhibits the progression of liver fibrosis via mediation of histone H2B lysine 120 ubiquitination

S Chen, X Dai, H Li, Y Gong, Y Zhao, H Huang - Human Cell, 2021 - Springer
Liver fibrosis is a chronic liver injury that leads to liver cirrhosis and liver cancer. Ring finger
protein 20 (RNF20), also named as E3 ubiquitin-protein ligase BRE1A, has been reported to …