This publication introduces a series of eight other publications describing the non-clinical
assessment and initial clinical study of a candidate modified risk tobacco product (MRTP) …

The lung is an organ that is directly exposed to the external environment. Given the large
surface area and extensive ventilation of the lung, it is prone to exposure to airborne …

For a tobacco heating product (THP), which heats rather than burns tobacco, the emissions
of toxicants in the aerosol were compared with those in cigarette smoke under a machine …

Abstract Introduction Tobacco Heating System 2.2 (THS 2.2, marketed as iQOS) is a heat-not-
burn (HNB) tobacco product that has been successfully introduced to global markets …

Abstract Introduction The menthol Tobacco Heating System 2.2 (mTHS) is a newly
developed candidate modified-risk tobacco product intended to reduce exposure to the …

Introduction Modified-risk tobacco products are expected to reduce exposure to harmful and
potentially harmful constituents of cigarette smoke, and ultimately reduce the health burden …

Tobacco-free 'modern'oral nicotine pouches (MOPs), are similar in appearance and use to
Swedish-style snus, but without tobacco. There are few identified methods to create test …

The recent rapid increase in the prevalence of emerging tobacco-and nicotine-containing
products, such as e-cigarettes, is being driven in part by their reduced-risk potential …

The use of novel tobacco-and nicotine-containing vapor products that do not combust
tobacco leaves is on the rise worldwide. The emissions of these products typically contain …

Various electronic nicotine delivery systems (ENDS), of which electronic cigarettes (e-cigs)
are the most recognized prototype, have been quickly gaining ground on conventional …