Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. It is a leading cause of chronic kidney disease and progresses to end-stage …

Abstract Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis
that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but …

IgA nephropathy is a common glomerular disease that is an important cause of kidney
failure. This review discusses advances in the therapy and understanding of the molecular …

Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …

Understanding the impact of glycosylation and keeping a close control on glycosylation of
product candidates are required for both novel and biosimilar monoclonal antibodies (mAbs) …

Recent years have brought notable progress in the field of IgA nephropathy. Here, we
highlight important new directions and latest developments, including successful discovery …

The vast surfaces of the gastrointestinal, respiratory, and genitourinary tracts represent
major sites of potential attack by invading micro‐organisms. Immunoglobulin A (IgA), as the …

The biosynthesis, structures, and functions of O-glycosylation, as a complex
posttranslational event, is reviewed and compared for the various types of O-glycans. Mucin …

Vol. 78, No. 6 Page 1 0025-7974/99/7806-0395/0 MEDICINE 978: 395-409, 1999 Copyright C
1999 by Lippincott Williams & Wilkins, Inc. Vol. 78, No. 6 Printed in USA Henoch-Schönlein …

IgA nephropathy (IgAN) is characterized by circulating immune complexes composed of
galactose-deficient IgA1 and a glycan-specific IgG antibody. These immune complexes …