Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …

There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …

Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …

The expression of acute-phase proteins (APP's) maintains homeostasis and tissue repair,
but also represents a central component of the organism's defense strategy, especially in the …

Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the
activation of immune cells in the damaged tissues. Macrophages have emerged as central …

Background: Pulmonary hypertension (PH) is associated with increased expression of VEGF-
A (vascular endothelial growth factor A) and its receptor, VEGFR2 (vascular endothelial …

Background Primary immune thrombocytopenia is an autoimmune disorder mediated partly
by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …

Abstract The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …