Why nanoparticles prefer liver macrophage cell uptake in vivo
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages …
Beyond hemostasis: platelet innate immune interactions and thromboinflammation
J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …
How we treat primary immune thrombocytopenia in adults
X Liu, Y Hou, M Hou - Journal of Hematology & Oncology, 2023 - Springer
Primary immune thrombocytopenia (ITP) is an immune-mediated bleeding disorder
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …
characterized by decreased platelet counts and an increased risk of bleeding. Multiple …
Acute-phase protein synthesis: a key feature of innate immune functions of the liver
C Ehlting, SD Wolf, JG Bode - Biological chemistry, 2021 - degruyter.com
The expression of acute-phase proteins (APP's) maintains homeostasis and tissue repair,
but also represents a central component of the organism's defense strategy, especially in the …
but also represents a central component of the organism's defense strategy, especially in the …
The role of macrophages in liver fibrosis: new therapeutic opportunities
Chronic inflammation is the hallmark of fibrotic disorders and is characterized by the
activation of immune cells in the damaged tissues. Macrophages have emerged as central …
activation of immune cells in the damaged tissues. Macrophages have emerged as central …
Targeting VEGF-A/VEGFR2 Y949 signaling-mediated vascular permeability alleviates hypoxic pulmonary hypertension
W Zhou, K Liu, L Zeng, J He, X Gao, X Gu, X Chen… - Circulation, 2022 - Am Heart Assoc
Background: Pulmonary hypertension (PH) is associated with increased expression of VEGF-
A (vascular endothelial growth factor A) and its receptor, VEGFR2 (vascular endothelial …
A (vascular endothelial growth factor A) and its receptor, VEGFR2 (vascular endothelial …
Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised …
CM Broome, V McDonald, Y Miyakawa, M Carpenedo… - The Lancet, 2023 - thelancet.com
Background Primary immune thrombocytopenia is an autoimmune disorder mediated partly
by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional …
by platelet autoantibodies, resulting in thrombocytopenia, bleeding, and constitutional …
Heterogeneity and function of kupffer cells in liver injury
W Li, N Chang, L Li - Frontiers in Immunology, 2022 - frontiersin.org
Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …
Macrophages as key regulators of liver health and disease
E Papachristoforou, P Ramachandran - International Review of Cell and …, 2022 - Elsevier
Macrophages are a heterogeneous population of innate immune cells and key cellular
components of the liver. Hepatic macrophages consist of embryologically-derived resident …
components of the liver. Hepatic macrophages consist of embryologically-derived resident …
The GPIb-IX complex on platelets: insight into its novel physiological functions affecting immune surveillance, hepatic thrombopoietin generation, platelet clearance …
G Bendas, M Schlesinger - Experimental Hematology & Oncology, 2022 - Springer
Abstract The glycoprotein (GP) Ib-IX complex is a platelet receptor that mediates the initial
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …
interaction with subendothelial von Willebrand factor (VWF) causing platelet arrest at sites of …