The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease
and is characterized by the degeneration of upper and lower motor neurons. It has become …

The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …

The ability to quantitate and visualize microRNAs (miRNAs) in situ in single cells would
greatly facilitate the elucidation of miRNA‐mediated regulatory circuits and their disease …

Background Astrocytes regulate neuronal function, synaptic formation and maintenance
partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) …

Although aberrant microRNA (miRNA) expression is linked to human diseases including
cancer, the mechanisms that regulate the expression of each individual miRNA remain …

Antisense techniques have been employed for over 30 years to suppress expression of
target RNAs. Recently, microRNAs (miRNAs) have emerged as a new class of small, non …

Soon after its discovery, microRNA-9 (miR-9) attracted the attention of neurobiologists, since
it is one of the most highly expressed microRNAs in the developing and adult vertebrate …

The function of human nervous system is critically dependent on proper interneuronal
communication. Exosomes and other extracellular vesicles are emerging as a novel form of …

Extracellular vesicles, including exosomes, are small membranous vesicles released from
many biotypes, contributing to the disease progression and spreading. These extracellular …