Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

A single protein, HMGB 1, directs the triggering of inflammation, innate and adaptive
immune responses, and tissue healing after damage. HMGB 1 is the best characterized …

The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer
development has increasingly been appreciated. Here, we present the detection and …

Background Multicellular organisms have evolved systems/mechanisms to detect various
forms of danger, including attack by microbial pathogens and a variety of pests, as well as …

Nucleosome positioning is critical for gene expression and most DNA-related processes.
Here we review the dominant patterns of nucleosome positioning that have been observed …

BAP1 is a deubiquitylase that is found associated with multiprotein complexes that regulate
key cellular pathways, including the cell cycle, cellular differentiation, cell death …

Skeletal muscle stem cells (also called satellite cells, SCs) are important for maintaining
muscle tissue homeostasis and damage-induced regeneration. However, it remains poorly …

The ability to maintain quiescence is critical for the long-term maintenance of a functional
stem cell pool. To date, the epigenetic and transcriptional characteristics of quiescent stem …