Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

In this Commentary, the authors expand on their earlier studies of the solid-state long-term
isothermal crystallization of amorphous API from the glassy state in amorphous solid …

Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Poor solubility is a major challenge that can limit the oral bioavailability of many drugs,
including delamanid, a weakly basic nitro-dihydro-imidazooxazole derivative used to treat …

Incorporating the amorphous drug in polymeric components has been demonstrated as a
feasible approach to enhance the bioavailability of poorly water-soluble drugs. The objective …

Numerous amorphous solid dispersion (ASD) formulations of celecoxib (CEL) have been
attempted for enhancing the solubility, dissolution rate, and in vivo pharmacokinetics via …

An amorphous drug–polymer salt (ADPS) can be remarkably stable against crystallization at
high temperature and humidity (eg, 40° C/75% RH) and provide fast release. Here, we …

Recent work has highlighted that amorphous solid dispersions (ASDs) containing
delamanid (DLM) and an enteric polymer, hypromellose phthalate (HPMCP), appear to be …

Crystalline drugs with low solubility have the potential to benefit from delivery in the
amorphous form. The polymers used in amorphous solid dispersions (ASDs) influence their …