Haemophilia care has undergone substantial improvements during the past 40–50 years.
Early clotting factor concentrates were not sufficiently refined to enable self-administered …

Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

During the past two decades, there have been numerous attempts at using animals in order
to produce recombinant human proteins and monoclonal antibodies. However, it is only …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

The demonstrated benefits of home care for haemophilia include improved quality of life,
less pain and disability, fewer hospitalizations, and less time lost from work or school …

Background: Lacunar strokes account for 25% of ischaemic strokes, but their precise
aetiology is unknown. Similarities between the retinal and cerebral small vessels mean that …

BACKGROUND AND OBJECTIVES: Autoantibodies inactivating the von Willebrand factor
(VWF) cleaving protease, ADAMTS-13, are among the most frequent causes of thrombotic …

Pigs have anatomical, physiological and genomic characteristics that make them highly
suitable for modeling human diseases. Genetically modified (GM) pig models of human …

Factor IX is a zymogen enzyme of the blood coagulation cascade. Inherited absence or
deficit of the IX functional factor causes bleeding disorder hemophilia B, which requires …

This paper methodologically compares the electro-fusion (EF) and intracytoplasmic injection
(ICI) methods, as well as simultaneous fusion/activation (SA) and delayed activation (DA), in …