Ossification is a tightly regulated process, performed by specialized cells called osteoblasts.
Dysregulation of this process may cause inadequate or excessive mineralization of bones or …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

Although bone responds to its mechanical environment, the cellular and molecular
mechanisms underlying the response of the skeleton to mechanical unloading are not …

Chronic (neuro) inflammation plays an important role in many age-related central nervous
system (CNS) diseases, including Alzheimer's disease, Parkinson's disease and vascular …

It has always been a desire of mankind to conquest Space. A major step in realizing this
dream was the completion of the International Space Station (ISS). Living there for several …

Background Efficient osteogenic differentiation is highly dependent on coordinated signals
arising from growth factor signalling and mechanical forces. Bone morphogenetic proteins …

Recent studies have demonstrated that miRNAs can play important roles in osteoblast
differentiation and bone formation. However, the function of miRNAs in bone loss induced by …

Mechanical loading represents a crucial factor in the regulation of skeletal homeostasis. Its
reduction causes loss of bone mass, eventually leading to osteoporosis. In a previous global …

Osteoporosis is a complex human disease that results in increased susceptibility to fragility
fractures. It can be phenotypically characterized using several traits, including bone mineral …

Rationale Vascular calcification is a prominent feature of late‐stage diabetes, renal and
cardiovascular disease (CVD), and has been linked to adverse events. Recent studies in …