Peptide-drug conjugates (PDCs) are the new hope for targeted therapy after antibody-drug
conjugates (ADCs). Compared with ADCs, the core advantages of PDCs are enhanced …

Traditional Chinese medicine (TCM) is the practical experience and summary of the
Chinese nation for thousands of years. It shows great potential in treating various chronic …

Solution synthesis afforded five novel neutral heteroleptic octahedral paramagnetic
mononuclear oxidovanadium (IV) complexes of general composition [VO (bpy) L], where L is …

Liver cancer is a malignant tumor that grows on the surface or inside the liver. The leading
cause is a viral infection with hepatitis B or C virus. Natural products and their structural …

Background Helicobacter pylori (H. pylori) is a persistent bacterial inhabitant in the stomachs
of approximately half the global populace. This bacterium is directly linked to chronic …

In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …

The search for novel powerful antimicrobial and antioxidant agents is considered a dynamic
field in medicinal chemistry. In this context, a series of spiropyrazoline indolin-3-one …

The aurora kinase is a key enzyme that is implicated in tumor growth. Research revealed
that small molecules that target aurora kinase have beneficial effects as anticancer agents …

A series of novel azepine derivatives based on quinazolinone moiety was synthesized
through the reaction of quinazolinone chalcones (2a–d) either with 2-amino aniline in acidic …

A small set of indole-based derivatives, IV and Va–I, was designed and synthesized.
Compounds Va–i demonstrated promising antiproliferative activity, with GI50 values ranging …