Chemistry and biology of multicomponent reactions

A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Metal-mediated and metal-catalyzed reactions of isocyanides

VP Boyarskiy, NA Bokach, KV Luzyanin… - Chemical …, 2015 - ACS Publications
1. INTRODUCTION A timely subtitle to this Review focused on conversions of isocyanides at
metal centers could have been “a platinum jubilee of the first metal-mediated reaction …

Multicomponent reactions for the synthesis of bioactive compounds: A review

CS Graebin, FV Ribeiro, KR Rogério… - Current Organic …, 2019 - ingentaconnect.com
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions …

Isocyanide-based multicomponent reactions for the synthesis of heterocycles

A Váradi, TC Palmer, R Notis Dardashti, S Majumdar - Molecules, 2015 - mdpi.com
Multicomponent reactions (MCRs) are extremely popular owing to their facile execution,
high atom-efficiency and the high diversity of products. MCRs can be used to access various …

Groebke–Blackburn–Bienaymé multicomponent reaction: emerging chemistry for drug discovery

S Shaaban, BF Abdel-Wahab - Molecular diversity, 2016 - Springer
Abstract The Groebke–Blackburn–Bienaymé reaction (GBBR) is used for the one-pot
synthesis of therapeutically relevant fused imidazoles bridgehead nitrogen heterocyclic …

N-Chlorosuccinimide-Promoted Regioselective Sulfenylation of Imidazoheterocycles at Room Temperature

C Ravi, D Chandra Mohan, S Adimurthy - Organic letters, 2014 - ACS Publications
N-Chlorosuccinimide-Promoted Regioselective Sulfenylation of Imidazoheterocycles at Room
Temperature | Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In …

Isocyanide based [4+ 1] cycloaddition reactions: an indispensable tool in multi-component reactions (MCRs)

T Kaur, P Wadhwa, S Bagchi, A Sharma - Chemical Communications, 2016 - pubs.rsc.org
The advent of cycloaddition reactions in the synthesis of heterocycles and their ever
burgeoning applications in the fields of material chemistry, catalysis and drugs have been a …

Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species

L El Kaim, L Grimaud - Tetrahedron, 2009 - Elsevier
The history of isocyanide chemistry goes back to the first synthesis of allyl isocyanide by
alkylation of silver cyanide reported by Lieke in 1859. 1 These isomers of cyanides …

Recent progress of isocyanide-based multicomponent reactions in Iran

A Shaabani, A Maleki, AH Rezayan, A Sarvary - Molecular diversity, 2011 - Springer
The aim of this review is to provide an overview of the contributions and recent advances
made by Iranian scientists in the field of isocyanide-based reactions between 1999 and …

Diversity-oriented synthesis of fused-imidazole derivatives via Groebke–Blackburn–Bienayme reaction: a review

N Devi, RK Rawal, V Singh - Tetrahedron, 2015 - Elsevier
In recent time, diversity-oriented synthesis of small chemical entities has been emerged as a
possible tool for exploring the intersections between chemistry and biology. These small …