Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Adipose tissue aging and metabolic disorder, and the impact of nutritional interventions

X Wang, M Xu, Y Li - Nutrients, 2022 - mdpi.com
Adipose tissue is the largest and most active endocrine organ, involved in regulating energy
balance, glucose and lipid homeostasis and immune function. Adipose tissue aging …

Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms

DJ Harney, M Cielesh, R Chu, KC Cooke, DE James… - Cell reports, 2021 - cell.com
Intermittent fasting is a beneficial dietary treatment for obesity. But the response of each
distinct adipose depot is currently poorly defined. Here we explore the response of key …

Early or delayed time-restricted feeding prevents metabolic impact of obesity in mice

P Regmi, R Chaudhary, AJ Page… - Journal of …, 2021 - joe.bioscientifica.com
Time-restricted feeding (TRF) initiated early during the dark phase prevents the metabolic
consequences of high fat diet in rodent models. However, the metabolic consequences of …

Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease

D Li, Y Dun, D Qi, JW Ripley-Gonzalez, J Dong… - Scientific Reports, 2023 - nature.com
Switching to normal diet (ND) is the regular therapy for high-fat diet (HFD)-induced
nonalcoholic fatty liver disease (NAFLD). Intermittent fasting (IF) is a unique treatment which …

Intermittent fasting: what questions should we be asking?

K Liu, B Liu, LK Heilbronn - Physiology & behavior, 2020 - Elsevier
Obesity and overweight are contributing factors to chronic disease. Lifestyle management,
which incorporates advice on moderate daily caloric restriction (CR) and physical activity to …

Time-restricted feeding improves body weight gain, lipid profiles, and atherogenic indices in cafeteria-diet-fed rats: role of browning of inguinal white adipose tissue

S Aouichat, M Chayah, S Bouguerra-Aouichat, A Agil - Nutrients, 2020 - mdpi.com
Time-restricted feeding (TRF) showed a potent effect in preventing obesity and improving
metabolicoutcomes in several animal models of obesity. However, there is, as of yet, scarce …

AAV-mediated BMP7 gene therapy counteracts insulin resistance and obesity

E Casana, V Jimenez, C Jambrina, V Sacristan… - … Therapy-Methods & …, 2022 - cell.com
Type 2 diabetes, insulin resistance, and obesity are strongly associated and are a major
health problem worldwide. Obesity largely results from a sustained imbalance between …