Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

The glutamate and dopamine hypotheses are leading theories of the pathoaetiology of
schizophrenia. Both were initially based on indirect evidence from pharmacological studies …

Aims Ketamine remains an important medicine in both specialist anaesthesia and aspects of
pain management. At the same time, its use as a recreational drug has spread in many parts …

Ketamine is a non-competitive antagonist at the N-methyl-d-aspartate receptor. It has
recently been found to have antidepressant effects and is a drug of abuse, suggesting it may …

The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine,
an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important …

OBJECTIVE: Research has implicated dysfunction of glutamatergic neurotransmission in the
pathophysiology of schizophrenia. This review evaluates evidence from preclinical and …

Background The N-methyl-d-aspartate receptor antagonist ketamine has rapid
antidepressant effects in major depression. Psychotomimetic symptoms, dissociation and …

Background: At least 10-20% of the patients suffering from depression meet criteria for
treatment-resistant depression (TRD). In the last decades, an important role of glutamate in …

Schizophrenia is a severe mental disorder associated with a characteristic constellation of
symptoms and neurocognitive deficits. At present, etiological mechanisms remain relatively …

Several groups have provided evidence that positron emission tomography (PET) and
single-photon emission computed tomography (SPECT) neuroreceptor imaging techniques …