In patients with decompensated cirrhosis, sarcopenia and frailty are prevalent. Although
several definitions exist for these terms, in the field of hepatology, sarcopenia has commonly …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here …

The biological basis of human aging remains one of the greatest unanswered scientific
questions. Increasing evidence, however, points to a role for alterations in mitochondrial …

In the past, illness and dependence were viewed as inevitable consequences of old age.
Now, we understand that there is a difference between age (the passing of chronological …

The notion of frailty has evolved for more than 15 years. Although there is no consensus
definition, frailty reflects a state of increased vulnerability to adverse health outcomes for …

Background Systemic chronic inflammation has been proposed as an essential mediating
factor in frailty, and several studies tested its relationship with frailty. However, the issue is …

Frailty is a geriatric condition associated with increased vulnerability to adverse drug events
and medication-related harm. Existing clinical practice guidelines rarely provide medication …

Studies on interventions that can delay or treat frailty in humans are limited. There is
evidence of beneficial effects of angiotensin converting enzyme (ACE) inhibitors on aspects …