Insight into structure activity relationship of DPP-4 inhibitors for development of antidiabetic agents
This article sheds light on the various scaffolds that can be used in the designing and
development of novel synthetic compounds to create DPP-4 inhibitors for the treatment of …
development of novel synthetic compounds to create DPP-4 inhibitors for the treatment of …
Fused azoloazines with antidiabetic activity
VL Rusinov, IM Sapozhnikova, AA Spasov… - Russian Chemical …, 2022 - Springer
The purpose of this review is to summarize drugs containing an azoloazine moiety and
exhibiting antidiabetic activity. The review includes azoloazines active against dipeptidyl …
exhibiting antidiabetic activity. The review includes azoloazines active against dipeptidyl …
Medicinal chemistry of non-peptidomimetic dipeptidyl peptidase IV (DPP IV) inhibitors for treatment of Type-2 diabetes mellitus: Insights on recent development
JP Ambhore, PR Laddha, A Nandedkar… - Journal of Molecular …, 2023 - Elsevier
Nowadays, dipeptidyl peptidase-IV (DPP-IV) is emerging as a hopeful drug target for treating
Type 2 diabetic mellitus (T2DM). Currently marketed DPP-IV inhibitors work by lowering the …
Type 2 diabetic mellitus (T2DM). Currently marketed DPP-IV inhibitors work by lowering the …
Click inspired novel pyrazole-triazole-persulfonimide & pyrazole-triazole-aryl derivatives; Design, synthesis, DPP-4 inhibitor with potential anti-diabetic agents
This work presented the first report on designing, synthesizing of novel pyrazole-triazole-
persulfonimide (7a-i) and pyrazole-triazole-aryl derivatives (8a-j) via click reaction using CuI …
persulfonimide (7a-i) and pyrazole-triazole-aryl derivatives (8a-j) via click reaction using CuI …
Recent advances in the biological significance of xanthine and its derivatives: a review
Xanthine is the most ubiquitous heterocyclic aromatic compound and have attracted much
synthetic interest due to their numerous pharmacological activities. It is one of the principal …
synthetic interest due to their numerous pharmacological activities. It is one of the principal …
One-pot synthesis of sulfonyl-1H-1,2,3-triazolyl-thiomorpholine 1,1-dioxide derivatives and evaluation of their biological activity
R Sreerama, VR N, S Narsimha - Phosphorus, Sulfur, and Silicon …, 2020 - Taylor & Francis
A one-pot procedure for the synthesis of novel 1, 2, 3-triazole derivatives (5a–5l) in good
yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl) thiomorpholine 1, 1 …
yields (63 to 77%) using different sulfonic acids and 4-(prop-2-yn-1-yl) thiomorpholine 1, 1 …
Recent Advances in the Synthesis of Xanthines: A Short Review
Xanthine and its derivatives are considered a pharmacologically potential moiety that
manifests immense biological activities. Owing to this much diversity in the biological field …
manifests immense biological activities. Owing to this much diversity in the biological field …
Coumarin-based sulfonamide derivatives as potential DPP-IV inhibitors: Pre-ADME analysis, toxicity profile, computational analysis, and in vitro enzyme assay
PK Vawhal, SB Jadhav, S Kaushik, KC Panigrahi… - Molecules, 2023 - mdpi.com
Recent research on dipeptidyl peptidase-IV (DPP-IV) inhibitors has made it feasible to treat
type 2 diabetes mellitus (T2DM) with minimal side effects. Therefore, in the present …
type 2 diabetes mellitus (T2DM) with minimal side effects. Therefore, in the present …
An insight into the combat strategies for the treatment of type 2 diabetes mellitus
Diabetes is a chronic, and metabolic disorder that has gained epidemic proportions in the
past few decades creating a threat throughout the globe. It is characterized by increased …
past few decades creating a threat throughout the globe. It is characterized by increased …
Recent advances and structure-activity relationship studies of DPP-4 inhibitors as anti-diabetic agents
S Singhal, VM Patil, S Verma, N Masand - Bioorganic Chemistry, 2024 - Elsevier
Diabetes mellitus (DM) is one of the largest public health problems worldwide and in the last
decades various therapeutic targetshave been investigated. For the treatment of type-2 DM …
decades various therapeutic targetshave been investigated. For the treatment of type-2 DM …