Bone morphogenetic proteins (BMPs) exhibit broad spectra of biological activities in various
tissues, including bone, cartilage, blood vessels, heart, kidney, neurons, liver and lung …

Much of the focus on the transforming growth factor-β (TGFβ) superfamily in cancer has
revolved around the TGFβ ligands themselves. However, it is now becoming apparent that …

Colorectal tumor is a heterogeneous disease, with varying clinical presentation and
prognosis in patients. To establish a platform encompassing this diversity, we generated 55 …

The intestinal epithelium possesses a remarkable self-renewal ability, which is mediated by
actively proliferating Lgr5+ stem cells. Bone morphogenetic protein (BMP) signalling …

Bone morphogenetic proteins (BMPs) are a diverse class of molecules with over 20 growth
factor proteins that belong to the transforming growth factor-β (TGF-β) family and are highly …

The identification of intestinal stem cells as well as their malignant counterparts, colon
cancer stem cells, has undergone rapid development in recent years. Under physiological …

Hereditary mixed polyposis syndrome (HMPS) is characterized by the development of mixed-
morphology colorectal tumors and is caused by a 40-kb genetic duplication that results in …

Mesenchymal cells in the intestine comprise a variety of cell types of diverse origins,
functions, and molecular markers. They provide mechanical and structural support and have …

Overactivation of Wnt signaling is a hallmark of colorectal cancer (CRC). The Wnt pathway is
a key regulator of both the early and the later, more invasive, stages of CRC development. In …

The mesenchymal elements of the intestinal lamina propria reviewed here are the
myofibroblasts, fibroblasts, mural cells (pericytes) of the vasculature, bone marrow–derived …