Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

The dramatic increase in opioid misuse, opioid use disorder (OUD), and opioid‐related
overdose deaths in the United States has led to public outcry, policy statements, and funding …

Stigma as a fundamental hindrance to the United States opioid overdose crisis response |
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The accepted wisdom about the US overdose crisis singles out prescribing as the causative
vector. Although drug supply is a key factor, we posit that the crisis is fundamentally fueled …

Background: Opioid use, abuse, and adverse consequences, including death, have
escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse …

Objective To examine the associations between stopping treatment with opioids, length of
treatment, and death from overdose or suicide in the Veterans Health Administration. Design …

Importance Prescription opioids are involved in 40% of all deaths from opioid overdose in
the United States and are commonly the first opioids encountered by individuals with opioid …

Objective: The International Patterns of Opioid Prescribing study compares postoperative
opioid prescribing patterns in the United States (US) versus the rest of the world. Summary …

Background A national crisis of opioid-related morbidity, mortality, and misuse has led to
initiatives to address the appropriate role of opioids to treat pain. Deployment of a guideline …

Improving the Supply and Quality of Deceased-Donor Organs for Transplantation | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …