Human and animal studies suggest an intriguing link between mitochondrial diseases and
depression. Although depression has historically been linked to alterations in …

Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Major depression is a serious disorder of enormous sociological and clinical relevance. The
discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of …

Deregulated cellular signalling is a common hallmark of disease, and delineating tissue
phosphoproteomes is key to unravelling the underlying mechanisms. Here we present the …

Bipolar, or manic-depressive, disorder is a frequent, severe, mostly recurrent mood disorder
associated with great morbidity. The lifetime prevalence of bipolar disorder is 1· 3 to 1· 6 …

Evidence suggests that Alzheimer disease (AD) begins as a disorder of synaptic function,
caused in part by increased levels of amyloid β-peptide 1–42 (Aβ42). Both synaptic and …

Magnetic resonance spectroscopy (MRS) affords a noninvasive window on in vivo brain
chemistry and, as such, provides a unique opportunity to gain insight into the biochemical …

Regulation of gene expression represents a major component in antidepressant drug action.
The effect of antidepressant treatments on the function of cAMP-responsive element binding …

The hippocampus plays a main role in regulating stress response in humans, but is itself
highly sensitive to neurotoxic effects of repeated stressful episodes. Hippocampal atrophy …

Bipolar illness is a major psychiatric disorder that affects 1–3% of the worldwide population.
Epidemiological studies have demonstrated that this illness is substantially heritable …