The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Superoxide dismutases (SODs) constitute a very important antioxidant defense against
oxidative stress in the body. The enzyme acts as a good therapeutic agent against reactive …

Hexavalent chromium is a highly soluble environmental contaminant. It is a widespread
anthropogenic chromium species that is 100 times more toxic than trivalent chromium …

Many short-lived and highly reactive oxygen species, such as superoxide anion (O2-) and
hydrogen peroxide (H2O2), are toxic or can create oxidative stress in cells, a response …

Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

Natural products derived from plants, as well as their bioactive compounds, have been
extensively studied in recent years for their therapeutic potential in a variety of …

Neurodegenerative diseases (NDDs) are conditions that cause neuron structure and/or
function to deteriorate over time. Genetic alterations may be responsible for several NDDs …

Significance: After approximatelty three decades of research, two Mn (III) porphyrins (MnPs),
MnTE-2-PyP5+ (BMX-010, AEOL10113) and MnTnBuOE-2-PyP5+ (BMX-001), have …

Significance: Cancer cells that are resistant to radiation and chemotherapy are a major
problem limiting the success of cancer therapy. Aggressive cancer cells depend on elevated …

Mn (III) ortho‐N‐alkyl‐and N‐alkoxyalkyl porphyrins (MnPs) were initially developed as
superoxide dismutase (SOD) mimics. These compounds were later shown to react with …