Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents

DJ Sheppard, SA Cameron, PC Tyler… - Organic & biomolecular …, 2020 - pubs.rsc.org
Late oxidation of hexose based building blocks or the use of uronic acid containing building
blocks are two complementary strategies in the synthesis of glycosaminoglycans, the latter …

Synthetic sulfated saccharides in cell signalling

D Sheppard - 2023 - openaccess.wgtn.ac.nz
Access to heparan sulfate-like oligosaccharides, displaying a specific sulfation pattern, is
chemically challenging but highly desirable for further insight into the relationship between …

[PDF][PDF] Crystal packing in three related disaccharides: precursors to heparan sulfate oligosaccharides

GJ Gainsford, R Schwörer, PC Tyler… - Acta Crystallographica …, 2015 - journals.iucr.org
The three title compounds form part of a set of important precursor dissacharides which lead
to novel therapeutics, in particular for Alzheimer's disease. All three crystallize as poorly …