Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …

Mitochondrial ribosomes (mitoribosomes) are tethered to the mitochondrial inner membrane
to facilitate the cotranslational membrane insertion of the synthesized proteins. We report …

Mitoribosomes are essential for the synthesis and maintenance of bioenergetic proteins.
Here we use cryo-electron microscopy to determine a series of the small mitoribosomal …

Mitochondria are one of the most important organelles in cells. Mitochondria are semi-
autonomous organelles with their own genetic system, and can independently replicate …

Translation of mitochondrial messenger RNA (mt-mRNA) is performed by distinct
mitoribosomes comprising at least 36 mitochondria-specific proteins. How these …

The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet
many molecular details of mitochondrial translation remain elusive. It has been commonly …

Mitochondria contain dedicated ribosomes (mitoribosomes), which synthesize the
mitochondrial-encoded core components of the oxidative phosphorylation complexes. The …

The genetic code that specifies the identity of amino acids incorporated into proteins during
protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations …

INTRODUCTION Ribosomes are universally conserved assemblies composed of ribosomal
RNA (rRNA) and proteins, where rRNA plays key structural and functional roles. Despite …