Gene knockout is a technique routinely used in basic experimental research, particularly in
mouse skeletal and developmental studies. Tamoxifen-induced Cre/loxp system is known …

Temporally controlling Cre recombination through tamoxifen (Tam) induction has many
advantages for biomedical research. Most studies report early post-natal/juvenile (< 2 mo) …

Tamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in
women and more recently to induce conditional gene editing in rodent hearts. However, little …

Abstract The Cre-LoxP system has been commonly used for cell-specific genetic
manipulation. However, many Cre strains exhibit excision activity in unexpected cell types or …

Background Though the CXCR2 chemokine receptor is known to play a key role in cancer
growth and response to therapy, a direct link between expression of CXCR2 in tumor …

Paralogs CDK8 and CDK19 are regulatory kinases associated with the transcriptional
Mediator complex. We have for the first time generated mice with the systemic inducible …

The mammary gland has a central role in optimal mammalian development and survival.
Contractions of smooth muscle-like basal (or myoepithelial) cells in the functionally mature …

The patterns by which primary tumors spread to metastatic sites remain poorly understood.
Here, we define patterns of metastatic seeding in prostate cancer using a novel injection …

Temporally controlling cre recombination through tamoxifen (Tam) induction has many
advantages for biomedical research. Most studies report Tam induction at early post …

The mammary gland has a central role in optimal mammalian development and survival.
Contractions of smooth muscle-like basal (or myoepithelial) cells in the functionally mature …