Telomere replication: solving multiple end replication problems
E Bonnell, E Pasquier, RJ Wellinger - Frontiers in Cell and …, 2021 - frontiersin.org
Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …
end protection from unwarranted fusions, recombination, and degradation in order to …
Replication protein A: a multifunctional protein with roles in DNA replication, repair and beyond
R Dueva, G Iliakis - NAR cancer, 2020 - academic.oup.com
Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …
important intermediate during recombination-mediated repair of damaged DNA. Replication …
A R-loop sensing pathway mediates the relocation of transcribed genes to nuclear pore complexes
A Penzo, M Dubarry, C Brocas, M Zheng… - Nature …, 2023 - nature.com
Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …
The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination
L Acquaviva, L Székvölgyi, B Dichtl, BS Dichtl… - Science, 2013 - science.org
During meiosis, combinatorial associations of genetic traits arise from homologous
recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks …
recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks …
Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue
Human telomere biology disorders (TBD)/short telomere syndromes (STS) are
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …
The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks
A Teixeira-Silva, A Ait Saada, J Hardy, I Iraqui… - Nature …, 2017 - nature.com
Replication requires homologous recombination (HR) to stabilize and restart terminally
arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps …
arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps …
Biology of telomeres: lessons from budding yeast
M Kupiec - FEMS microbiology reviews, 2014 - academic.oup.com
Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …
Structural insights into yeast telomerase recruitment to telomeres
H Chen, J Xue, D Churikov, EP Hass, S Shi, LD Lemon… - Cell, 2018 - cell.com
Telomerase maintains chromosome ends from humans to yeasts. Recruitment of yeast
telomerase to telomeres occurs through its Ku and Est1 subunits via independent …
telomerase to telomeres occurs through its Ku and Est1 subunits via independent …
RPA prevents G‐rich structure formation at lagging‐strand telomeres to allow maintenance of chromosome ends
J Audry, L Maestroni, E Delagoutte, T Gauthier… - The EMBO …, 2015 - embopress.org
Replication protein A (RPA) is a highly conserved heterotrimeric single‐stranded DNA‐
binding protein involved in DNA replication, recombination, and repair. In fission yeast, the …
binding protein involved in DNA replication, recombination, and repair. In fission yeast, the …
Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli
Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans
and other wild and domestic mammals across Central and South America. It does not cause …
and other wild and domestic mammals across Central and South America. It does not cause …