Eukaryotic genomes are highly complex and divided into linear chromosomes that require
end protection from unwarranted fusions, recombination, and degradation in order to …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

Nuclear pore complexes (NPCs) have increasingly recognized interactions with the
genome, as exemplified in yeast, where they bind transcribed or damaged chromatin. By …

During meiosis, combinatorial associations of genetic traits arise from homologous
recombination between parental chromosomes. Histone H3 lysine 4 trimethylation marks …

Human telomere biology disorders (TBD)/short telomere syndromes (STS) are
heterogeneous disorders caused by inherited loss-of-function mutations in telomere …

Replication requires homologous recombination (HR) to stabilize and restart terminally
arrested forks. HR-mediated fork processing requires single stranded DNA (ssDNA) gaps …

Telomeres are nucleoprotein structures that cap the ends of the linear eukaryotic
chromosomes and thereby protect their stability and integrity. Telomeres play central roles in …

Telomerase maintains chromosome ends from humans to yeasts. Recruitment of yeast
telomerase to telomeres occurs through its Ku and Est1 subunits via independent …

Replication protein A (RPA) is a highly conserved heterotrimeric single‐stranded DNA‐
binding protein involved in DNA replication, recombination, and repair. In fission yeast, the …

Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans
and other wild and domestic mammals across Central and South America. It does not cause …