Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …

Plasmodium has evolved to regulate the levels and oxidative states of iron protoporphyrin IX
(Fe-PPIX). Antimalarial endoperoxides such as 1, 2, 4-trioxane artemisinin and 1, 2, 4 …

Malaria is one of our planet's most widespread and deadliest diseases, and there is an ever-
consistent need for new and improved pharmaceuticals. Natural products have been an …

Amongst different forms of leishmaniasis, visceral leishmaniasis caused by L. donovani is
highly mortal. Identification of new hit compounds might afford new starting points to develop …

Malaria is one of the most widespread diseases worldwide. Besides a growing number of
people potentially threatened by malaria, the consistent emergence of resistance against …

Background Malaria is a life-threatening disease prevalent in tropical and subtropical
regions. Artemisinin combination therapy (ACT) used as an antimalarial treatment has …

Malaria, a mosquito‐borne parasitic infection caused by protozoan parasites belonging to
the genus Plasmodium, is a dangerous disease that contributes to millions of hospital visits …

In response to the spread of artemisinin (ART) resistance, ART-based hybrid drugs were
developed, and their activity profile was characterized against drug-sensitive and drug …

Drug resistance often emerges from mutations in solute transporters. Single amino acid
exchanges may alter functionality of transporters with 'de novo'ability to transport drugs away …

With the inexorable prevalence and spread of drug-resistant malaria strains, many efforts
have been made to find alternative chemotherapeutic agents. In this regard, scientists have …