Galectin-3 is a member of the galectin family, which are β‑galactoside‑binding lectins with≥
1 evolutionary conserved carbohydrate‑recognition domain. It binds proteins in a …

Galectin-3 (Gal-3) regulates basic cellular functions such as cell–cell and cell–matrix
interactions, growth, proliferation, differentiation, and inflammation. It is not surprising …

Pulmonary hypertension (PH) in neonates, infants, children, adolescents, and young adults
is a complex condition that can be associated with several cardiac, pulmonary, and systemic …

Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

In the summer of 2016, delegates from the German Society of Cardiology (DGK), the
German Respiratory Society (DGP), and the German Society of Pediatric Cardiology (DGPK) …

Fibrosis, stiffening and scarring of an organ/tissue due to genetic abnormalities,
environmental factors, infection, and/or injury, is responsible for> 40% of all deaths in the …

Germline mutations involving small mothers against decapentaplegic–transforming growth
factor–β (SMAD–TGF-β) signaling are an important but rare cause of pulmonary arterial …

Aldosterone controls salt–water homeostasis by acting on the mineralocorticoid receptor
(MR), a ligand-activated transcription factor, in kidney epithelial cells. However, it is now …

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac
fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory …

A defining characteristic of pulmonary hypertension (PH) is the extensive remodeling of
pulmonary arteries (PAs), which results in progressive increases in vascular resistance and …