Calcineurin inhibitors (CNIs) are both the savior and Achilles' heel of kidney transplantation.
Although CNIs have significantly reduced rates of acute rejection, their numerous toxicities …

Solid organ transplantation is an established treatment modality in patients with end-stage
organ damage in cases where other therapeutic options fail. The long-term outcomes of …

Hematopoietic stem cell transplantation is a life-saving therapy for many patients with
cancer, as well as patients with some nonmalignant hematologic disorders, such as aplastic …

Hematopoietic stem cell transplantation (HSCT) is a highly effective treatment strategy for
lymphoproliferative disorders and bone marrow failure states including aplastic anemia and …

BACKGROUND: Renin-expressing cells are myoendocrine cells crucial for the maintenance
of homeostasis. Renin is regulated by cAMP, p300 (histone acetyltransferase p300)/CBP …

Introduction Despite significant advancements in immunosuppressive regimens and surgical
techniques, the prevalence of adverse events related to immunosuppression remains a …

To add new molecular and pathogenetic insights into the biological machinery associated to
kidney allograft fibrosis is a major research target in nephrology and organ transplant …

Nephrotoxicity is the major adverse reaction to tacrolimus; however, the underlying
mechanisms remain to be fully elucidated. Although several tacrolimus-induced …

Hematopoietic cell transplant (HCT), used for treatment of many malignant and non-
malignant pediatric diseases, is associated with serious complications, limiting this therapy's …

The science of drug delivery has evolved considerably and has led to the development of
multiple sustained release formulations. Each of these formulations can present particular …