Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
Mutations in BRCA1 or BRCA2 (BRCA) is synthetic lethal with poly (ADP-ribose)
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
polymerase inhibitors (PARPi). Lethality is thought to derive from DNA double-stranded …
Revisiting the BRCA-pathway through the lens of replication gap suppression:“Gaps determine therapy response in BRCA mutant cancer”
SB Cantor - DNA repair, 2021 - Elsevier
The toxic lesion emanating from chemotherapy that targets the DNA was initially debated,
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …
but eventually the DNA double strand break (DSB) ultimately prevailed. The reasoning was …