The signaling lymphocyte activation molecule (SLAM)-associated protein, SAP, was first
identified as the protein affected in most cases of X-linked lymphoproliferative (XLP) …

Natural killer (NK) cells play a pivotal role in the immune system, especially in the
recognition and clearance of cancer cells and infected cells. Their effector function is …

Bone marrow transplantation is regarded as the most effective immunotherapy for
hematologic cancer, but it generally faces difficulties in matching. Aberrant expression of …

Prostate cancer is the most common type of cancer diagnosed and the second leading
cause of cancer-related death in American men. Natural Killer (NK) cells are the first line of …

Background Acute myeloid leukemia (AML) is the most common type of acute leukemia in
adults. Given the high relapse rate, more effective treatments are needed to improve clinical …

Abstract PML-RARA and AML1-ETO are important oncogenic fusion proteins that play a
central role in transformation to acute myeloid leukemia (AML). Whether these fusion …

The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a
group of receptors belonging to the CD2 family. It is composed of several members …

2B4 (CD244) is an important activating receptor for the regulation of natural killer (NK) cell
responses. Here we show that 2B4 is heavily and differentially glycosylated in primary …

Human NK cells can be activated by a variety of different cell surface receptors. Members of
the SLAM-related receptors (SRR) are important modulators of NK cell activity. One …

[Frontiers in Bioscience 13, 956-965, January 1, 2008] 956 Regulation of NK cell activity by
2B4, NTB-A and CRACC Maren Claus1, Page 1 [Frontiers in Bioscience 13, 956-965, January …