[HTML][HTML] Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery
DB Kell, R Goodacre - Drug Discovery Today, 2014 - Elsevier
Highlights•We now have metabolic network models; the metabolome is represented by their
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …
nodes.•Metabolite levels are sensitive to changes in enzyme activities.•Drugs hitchhike on …
[PDF][PDF] Metabolomics in medical sciences ń trends, challenges and perspectives
A KLUPCZY—SKA, P DEREZI—SKI… - Acta poloniae …, 2015 - ptfarm.pl
Metabolomics is the latest of the ěomicî technologies that involves comprehensive analysis
of small molecule metabolites of an organism or a specific biological sample. Metabolomics …
of small molecule metabolites of an organism or a specific biological sample. Metabolomics …
[HTML][HTML] Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases
AIM: To evaluate the utility of serum and urine metabolomic analysis in diagnosing and
monitoring of inflammatory bowel diseases (IBD). METHODS: Serum and urine samples …
monitoring of inflammatory bowel diseases (IBD). METHODS: Serum and urine samples …
Investigation of faecal volatile organic metabolites as novel diagnostic biomarkers in inflammatory bowel disease
Background The aetiology of inflammatory bowel disease (IBD) remains poorly understood.
Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may …
Recent evidence suggests an important role of gut microbial dysbiosis in IBD, and this may …
Serum metabolic disturbances in lung cancer investigated through an elaborative NMR-based serum metabolomics approach
Detection of metabolic disturbances in lung cancer (LC) has the potential to aid early
diagnosis/prognosis and hence improve disease management strategies through reliable …
diagnosis/prognosis and hence improve disease management strategies through reliable …
[HTML][HTML] Metabolomic analysis of human cirrhosis, hepatocellular carcinoma, non-alcoholic fatty liver disease and non-alcoholic steatohepatitis diseases
A Safaei, AA Oskouie, SR Mohebbi… - … and hepatology from …, 2016 - ncbi.nlm.nih.gov
Metabolome analysis is used to evaluate the characteristics and interactions of low
molecular weight metabolites under a specific set of conditions. In cirrhosis, hepatocellular …
molecular weight metabolites under a specific set of conditions. In cirrhosis, hepatocellular …
Identification of biomarkers for apoptosis in cancer cell lines using metabolomics: tools for individualized medicine
A Halama, N Riesen, G Möller… - Journal of internal …, 2013 - Wiley Online Library
Background Metabolomics is a versatile unbiased method to search for biomarkers of
human disease. In particular, one approach in cancer therapy is to promote apoptosis in …
human disease. In particular, one approach in cancer therapy is to promote apoptosis in …
The Fanconi anemia pathway: repairing the link between DNA damage and squamous cell carcinoma
LE Romick-Rosendale, VWY Lui, JR Grandis… - Mutation Research …, 2013 - Elsevier
Fanconi anemia (FA) is a rare inherited recessive disease caused by mutations in one of
fifteen genes known to encode FA pathway components. In response to DNA damage …
fifteen genes known to encode FA pathway components. In response to DNA damage …
Serum microRNA signatures and metabolomics have high diagnostic value in gastric cancer
HN Liu, H Wu, YJ Tseng, YJ Chen, DY Zhang, L Zhu… - BMC cancer, 2018 - Springer
Background Many novel diagnostic biomarkers have been developed for gastric cancer
(GC) recently. We chose two methods with high diagnostic value, the detection of serum …
(GC) recently. We chose two methods with high diagnostic value, the detection of serum …
[HTML][HTML] Application of metabolomics in drug resistant breast cancer research
AN Shajahan-Haq, MS Cheema, R Clarke - Metabolites, 2015 - mdpi.com
The metabolic profiles of breast cancer cells are different from normal mammary epithelial
cells. Breast cancer cells that gain resistance to therapeutic interventions can reprogram …
cells. Breast cancer cells that gain resistance to therapeutic interventions can reprogram …