The reactive oxygen species in macrophage polarization: reflecting its dual role in progression and treatment of human diseases

HY Tan, N Wang, S Li, M Hong… - … medicine and cellular …, 2016 - Wiley Online Library
High heterogeneity of macrophage is associated with its functions in polarization to different
functional phenotypes depending on environmental cues. Macrophages remain in balanced …

Biodistribution, clearance, and long‐term fate of clinically relevant nanomaterials

J Bourquin, A Milosevic, D Hauser, R Lehner… - Advanced …, 2018 - Wiley Online Library
Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …

Streptococcus pneumoniae's Virulence and Host Immunity: Aging, Diagnostics, and Prevention

LRK Brooks, GI Mias - Frontiers in immunology, 2018 - frontiersin.org
Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

Iron as a central player and promising target in cancer progression

M Jung, C Mertens, E Tomat, B Brüne - International journal of molecular …, 2019 - mdpi.com
Iron is an essential element for virtually all organisms. On the one hand, it facilitates cell
proliferation and growth. On the other hand, iron may be detrimental due to its redox …

Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction

G Zizzo, BA Hilliard, M Monestier… - The Journal of …, 2012 - journals.aai.org
Mer tyrosine kinase (MerTK) is a major macrophage apoptotic cell (AC) receptor. Its
functional impairment promotes autoimmunity and atherosclerosis, whereas overexpression …

Transforming growth factor-β regulation of immune responses

MO Li, YY Wan, S Sanjabi, AKL Robertson… - Annu. Rev …, 2006 - annualreviews.org
Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Heterogeneity of microglial activation in the innate immune response in the brain

CA Colton - Journal of neuroimmune pharmacology, 2009 - Springer
The immune response in the brain has been widely investigated and while many studies
have focused on the proinflammatory cytotoxic response, the brain's innate immune system …

In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies

NC Peters, JG Egen, N Secundino, A Debrabant… - Science, 2008 - science.org
Infection with the obligate intracellular protozoan Leishmania is thought to be initiated by
direct parasitization of macrophages, but the early events following transmission to the skin …

Apoptosis: a basic biological phenomenon with wide‐ranging implications in human disease

B Fadeel, S Orrenius - Journal of internal medicine, 2005 - Wiley Online Library
Apoptosis is a highly regulated process of cell deletion and plays a fundamental role in the
maintenance of tissue homeostasis in the adult organism. Numerous studies in recent years …

Alcohol, oxidative stress and free radical damage

E Albano - Proceedings of the nutrition society, 2006 - cambridge.org
The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …