Pathogenesis of autoimmune disease

DS Pisetsky - Nature Reviews Nephrology, 2023 - nature.com
Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell
and T cell reactivity to normal constituents of the host. These diseases occur widely and …

The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention

FW Miller - Current opinion in immunology, 2023 - Elsevier
Highlights•Autoimmunity is defined by a self-reactive adaptive immune system, causing
clinical pathology in autoimmune diseases.•Evidence suggests that autoimmunity and …

Gut microbiota dysbiosis: triggers, consequences, diagnostic and therapeutic options

T Hrncir - Microorganisms, 2022 - mdpi.com
The global incidence of numerous immune-mediated, metabolic, neurodegenerative, and
psychiatric diseases is steadily increasing [1–3]. The increased morbidity of human …

Autoimmune pre-disease

K Bieber, JE Hundt, X Yu, M Ehlers, F Petersen… - Autoimmunity …, 2023 - Elsevier
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Diagnosis and management of autoimmune hepatitis

L Muratori, AW Lohse, M Lenzi - bmj, 2023 - bmj.com
Autoimmune hepatitis is an inflammatory disease of the liver of unknown cause that may
progress to liver cirrhosis and end stage liver failure if diagnosis is overlooked and treatment …

[HTML][HTML] Xist ribonucleoproteins promote female sex-biased autoimmunity

DR Dou, Y Zhao, JA Belk, Y Zhao, KM Casey, DC Chen… - Cell, 2024 - cell.com
Autoimmune diseases disproportionately affect females more than males. The XX sex
chromosome complement is strongly associated with susceptibility to autoimmunity. Xist …

Long-term symptom severity and clinical biomarkers in post-COVID-19/chronic fatigue syndrome: results from a prospective observational cohort

F Legler, L Meyer-Arndt, L Mödl, C Kedor… - …, 2023 - thelancet.com
Summary Background Post-COVID-19 syndrome (PCS) is characterised by a wide range of
symptoms, primarily fatigue and exertion intolerance. While disease courses in the early …

A break in mitochondrial endosymbiosis as a basis for inflammatory diseases

MP Murphy, LAJ O'Neill - Nature, 2024 - nature.com
Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Association between long-term exposure to air pollution and immune-mediated diseases: a population-based cohort study

G Adami, M Pontalti, G Cattani, M Rossini… - RMD open, 2022 - rmdopen.bmj.com
Objective Environmental air pollution has been associated with disruption of the immune
system at a molecular level. The primary aim of the present study was to describe the …

Epigenetic regulation and T-cell responses in endometriosis–something other than autoimmunity

D Szukiewicz - Frontiers in immunology, 2022 - frontiersin.org
Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …