Patients with rheumatic diseases, including rheumatoid arthritis and osteoarthritis, almost
universally describe pain and stiffness as important contributors to reduced health-related …

Impaired diabetic wounds are serious pathophysiological complications associated with
persistent microbial infections including failure in the closure of wounds, and the cause of a …

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of often chemically unrelated
compounds with some common therapeutic actions and side effects. They have potent anti …

During the past decade a plethora of studies have unravelled the multiple roles of nitric
oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is …

Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …

Paracetamol has a central analgesic effect that is mediated through activation of descending
serotonergic pathways. Debate exists about its primary site of action, which may be …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-
inflammatory, antipyretic, and analgesic properties. However, their use is often associated …

During the 1980s, the free radical, nitric oxide (NO), was discovered to be a crucial
signalling molecule, with wide‐ranging functions in the cardiovascular, nervous and immune …

Historically, anti-inflammatory drugs had their origins in the serendipitous discovery of
certain plants and their extracts being applied for the relief of pain, fever and inflammation …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …