This is the part II of a tutorial review intending to give an overview of the state of the art of
method validation in liquid chromatography mass spectrometry (LC–MS) and discuss …

The substitution method—an empirical approach for uncertainty assessment (adapted from
the ISO 15530-3 guidelines) that is based on a comparison between repeated …

This review and commentary sets out the need for authoritative and concise information on
the expected error distributions and magnitudes in observational data. We discuss the …

X-ray computed tomography (CT) is uniquely suited for dimensional measurement of
components having internal geometry, difficult-to-reach part features, and easy-to-deform or …

The “purity” of an organic compound typically refers, in practice, to an assignment of the
mass fraction content of the primary organic component present in the material. The “purity” …

Abstract The NISTmAb Reference Material (RM) 8671 is intended to be an industry standard
monoclonal antibody for pre-competitive harmonization of best practices and designing next …

Physicians increasingly use laboratory-produced information for disease diagnosis, patient
monitoring, treatment planning, and evaluations of treatment effectiveness. Bias is the …

Clinical chemistry uses automated measurement techniques and medical knowledge in the
interest of patients and healthy subjects. Automation has reduced repeatability and day-to …

The present overview of validation and verification procedures in clinical chemistry focuses
on the use of harmonized concepts and nomenclature, fitness-for-purpose evaluations and …

The international standard ISO 15189 requires that medical laboratories estimate the
uncertainty of their quantitative test results obtained from patients' specimens. The standard …