Proteolysis targeting chimeric molecules (PROTACs) with functional handles and uses thereof

JA Johnson, HV Nguyen, Y Jiang, A Detappe… - US Patent …, 2024 - Google Patents
QCULBRPVCWJUKY-OUMVKTTMSA-N (2S, 4R)-N-[[2-[2-[2-[2-[4-[3-amino-6-(2-
hydroxyphenyl) pyridazin-4-yl] piperazin-1-yl] ethoxy] ethoxy] ethoxy]-4-(4-methyl-1, 3 …

Degradable polymers of a cyclic silyl ether and uses thereof

JA Johnson, P Shieh, W Zhang - US Patent 11,897,905, 2024 - Google Patents
2021-12-30 Assigned to MASSACHUSETTS INSTITUTE OF TECHNOLOGY reassignment
MASSACHUSETTS INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS …

Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent

JA Johnson, HV Nguyen, P Shieh, W Wang… - US Patent …, 2024 - Google Patents
2023-01-09 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …