As intensive treatment to lower levels of HbA1c characteristically results in an increased risk
of hypoglycaemia, patients with diabetes mellitus face a life-long optimization problem to …

The first systems for continuous glucose monitoring (CGM) became available over 15 years
ago. Many then believed CGM would revolutionize the use of intensive insulin therapy in …

Background A closed-loop system of insulin delivery (also called an artificial pancreas) may
improve glycemic outcomes in children with type 1 diabetes. Methods In a 16-week …

ISPAD Clinical Practice Consensus Guidelines 2018: Diabetes technologies Page 1 ISPAD
CLINICAL PRACTICE CONSENSUS GUIDELINES ISPAD Clinical Practice Consensus …

Background: A new version of the UVA/Padova Type 1 Diabetes (T1D) Simulator is
presented which provides a more realistic testing scenario. The upgrades to the previous …

Abstract Since Banting and Best isolated insulin in the 1920s, dramatic progress has been
made in the treatment of type 1 diabetes mellitus (T1DM). However, dose titration and timely …

OBJECTIVE Intense exercise is a major challenge to the management of type 1 diabetes
(T1D). Closed-loop control (CLC) systems (artificial pancreas) improve glycemic control …

Background: In the past few years, the artificial pancreas—the commonly accepted term for
closed-loop control (CLC) of blood glucose in diabetes—has become a hot topic in research …

Objective: Design and assessment of new therapies for type 1 diabetes (T1D) management
can be greatly facilitated by in silico simulations. The ReplayBG simulation methodology …

Automated insulin delivery (AID) systems, so-called closed-loop systems or artificial
pancreas, are based upon the concept of insulin supply driven by blood glucose levels and …