Cancer genomes contain large numbers of somatic mutations but few of these mutations
drive tumor development. Current approaches either identify driver genes on the basis of …

Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) is a specific transcription factor with
potent effects on the regulation of antioxidant gene expression that modulates cell …

The skin functions as a barrier between the organism and the surrounding environment.
Direct exposure to external stimuli and the accumulation of genetic mutations may lead to …

Objectives Temozolomide (TMZ) resistance is a key factor that restricts the therapeutic effect
of glioblastoma (GBM). YTH‐domain family member 2 (YTHDF2) is highly expressed in GBM …

Unrestrained transcriptional activity of β-CATENIN and its binding partner TCF7L2 frequently
underlies colorectal tumor initiation and is considered an obligatory oncogenic driver …

Neuroendocrine differentiation (NED) is associated with WNT signaling activation and can
be significantly observed after failure of androgen-deprivation therapy (ADT) for prostatic …

An important factor in the emergence and progression of osteosarcoma (OS) is the
dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a …

A major problem of colorectal cancer (CRC) targeted therapies is relapse caused by drug
resistance. In most cases of CRC, patients develop resistance to anticancer drugs …

Introduction The RNA-binding protein AU-rich-element factor-1 (AUF-1) participates to
posttranscriptional regulation of genes involved in inflammation and cellular senescence …

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide, with
high morbidity, relapse, metastasis and mortality rates. Although liver surgical resection …