Document Reviewers b, Petr Widimsky, Philippe Kolh, Stefan Agewall, Héctor Bueno,
Antonio Coca, Gert J. De Borst, Victoria Delgado, Florian Dick, Cetin Erol, Marc Ferrini …

Importance Chronic critical limb ischemia, marked by intractable lower extremity ischemic
rest pain and tissue loss, is a highly morbid condition that leads to the loss of ambulation …

W 2011 roku ESC opublikowało pierwsze wytyczne dotyczące rozpoznawania i leczenia
chorób tętnic obwodowych (PAD)[1]. Ta publikacja wypełniła ważną lukę wśród wytycznych …

The age-adjusted prevalence of peripheral arterial disease in the US population was
estimated to approach 12% in 1985, and as the population ages, the overall population …

Background Infection is a common epiphenomenon of advanced diabetic foot disease and
the most common reason for diabetes-related hospitalizations and lower extremity …

Aging is associated with a progressive loss of function in all organs. Under normal
conditions the physiologic compensation for age-related deficits is sufficient, but during …

Peripheral artery disease is a common disorder and a major cause of morbidity and mortality
worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events …

A third of patients with critical limb ischemia (CLI) will eventually require limb amputation.
Therapeutic neovascularization using unselected mononuclear cells to salvage ischemic …

Background Peripheral arterial occlusive disease (PAOD) is a common cause of morbidity
and mortality due to cardiovascular disease in the general population. Although numerous …

Background Cell‐based therapies involving mononuclear cells (MNC s) have been
developed for vascular regeneration to treat ischemic diseases; however, quality control of …