Starting as a glutamate producer, Corynebacterium glutamicum has played a variety of roles
in the industrial production of amino acids, one of the most important areas of white …

Carbon dioxide formation mirrors the final carbon oxidation steps of aerobic metabolism in
microbial and mammalian cells. As a consequence, CO 2/HCO 3− dissociation equilibria …

Adaptive laboratory evolution has proven a valuable strategy for metabolic engineering.
Here, we established an experimental evolution approach for improving microbial …

The productivity of industrial fermentation processes is essentially limited by the biomass-
specific substrate consumption rate (qS) of the applied microbial production system. Since …

The label-free and sensitive detection of synthesis products from single microbial cells
remains the bottleneck for determining the specific turnover numbers of individual whole-cell …

In this expert handbook both the topics and contributors are selected so as to provide an
authoritative view of possible applications for this new technology. The result is an up-to …

Evolutionary approaches are often undirected and mutagen-based yielding numerous
mutations, which need elaborate screenings to identify relevant targets. We here apply …

Scale‐up is usually complicated by the fact that bioprocesses in general are gas–liquid
systems, whereby the liquid phase also includes the specific biological component, which is …

The exploration of scale-down models to imitate the influence of large scale bioreactor
inhomogeneities on cellular metabolism is a topic with increasing relevance. While …

Population heterogeneity among a microbial culture can occur in various stages of a
bioprocess. When a nutrient-limited fed-batch process is applied in the large scale, gradient …