Cancer cells are well-known for adapting their metabolism to maintain high proliferation
rates and survive in unfavorable environments with low oxygen and nutritional deficiency …

The tumor microenvironment is proposed to contribute substantially to the progression of
cancers, including breast cancer. Cancer‐associated fibroblasts (CAFs) are the most …

In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …

Colorectal cancer (CRC), and breast, ovarian, pancreatic and prostate cancers are generally
considered as low immune-reactive cancers that represent either limited infiltration of …

Cancer-associated fibroblasts (CAFs) are critical components of the tumor microenvironment
(TME) with diverse functions such as extracellular matrix (ECM) remodeling, modulation of …

Cancer-associated fibroblasts (CAFs) are one of the most prominent and active components
in the pancreatic tumor microenvironment. Our data show that CAFs are critical for survival …

Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Solid cancers comprise a large number of new cases and deaths from cancer each year
globally. There are a number of strategies for addressing tumors raised from solid organs …

Cancer cells resistance to various therapies remains to be a key challenge nowadays. For a
long time, scientists focused on tumor cells themselves for the mechanisms of acquired drug …

Stromal heterogeneity of tumor microenvironment (TME) plays a crucial role in malignancy
and therapeutic resistance. Cancer-associated fibroblasts (CAFs) are one of the major …