Although bradykinesia, tremor and rigidity are the hallmark motor defects in patients with
Parkinson's disease (PD), patients also experience motor learning impairments and non …

Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity
via the activation of engineered receptors that are pharmacologically selective to …

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a
common neuropathological feature in many neurodevelopmental disorders. Rett syndrome …

Fear learning is a critical feature of survival skills among mammals. In rodents, fear learning
manifests itself through direct experience of the aversive event or social transmission of …

Background The ability to differentiate stimuli that predict fear is critical for survival; however,
the underlying molecular and circuit mechanisms remain poorly understood. Methods We …

Appropriate responding to threat and reward is essential to survival. The nucleus
accumbens core (NAcc) is known to support and organize reward behavior. The NAcc is …

Clinical studies have shown that social defeat is an important cause of mood-related
disorders, accompanied by learning and memory impairment in humans. The mechanism of …

Rett syndrome (RTT) is a neurodevelopmental disorder that is characterized by
developmental regression, loss of communicative ability, stereotyped hand wringing …

Stress‐induced neuroepigenetic programming gains growing more and more interest in the
studies of the etiology of posttraumatic stress disorder (PTSD). However, seldom attention is …

Background Posttraumatic stress disorder (PTSD), a psychiatric disorder caused by stressful
events, is characterized by long-lasting fear memory. The nucleus accumbens shell (NAcS) …