Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

The transcription factor p63 is a master regulator of epidermal development. Mutations in
p63 give rise to human developmental diseases that often manifest epidermal defects. In this …

The tumor protein p63 (p63), and more specifically the NH2-terminal truncated (ΔN) p63
isoform, is a marker of basal epithelial cells and is required for normal development of …

Since its discovery 40 years ago, fibroblast growth factor (FGF) receptor (FGFR) signalling
has been found to regulate fundamental cellular behaviours in a wide range of cell types …

Craniofacial development involves several complex tissue movements including several
fusion processes to form the frontonasal and maxillary structures, including the upper lip and …

The transcription factor p63 plays a pivotal role in keratinocyte proliferation and
differentiation in the epidermis. However, how p63 regulates epidermal genes during …

Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective
treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its …

Palatogenesis involves the initiation, growth, morphogenesis, and fusion of the primary and
secondary palatal shelves from initially separate facial prominences during embryogenesis …

Although p53 has long been known as the “guardian of the genome” with a role in tumor
suppression in many tissues, the discovery of two p53 ancestral genes, p63 and p73, more …

Cleft lip, which results from impaired facial process growth and fusion, is one of the most
common craniofacial birth defects. Many genes are known to be involved in the etiology of …