Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …

Physical exercise can improve brain function and delay neurodegeneration; however, the
initial signal from muscle to brain is unknown. Here we show that the lactate receptor …

Brain vascular calcification is a prevalent age-related condition often accompanying
neurodegenerative and neuroinflammatory diseases. The pathogenesis of large-vessel …

Pericytes are perivascular mural cells of brain capillaries. They are positioned centrally in
the neurovascular unit between endothelial cells, astrocytes and neurons. This position …

Injectable hydrogels can provide a scaffold for in situ tissue regrowth and regeneration, yet
gel degradation before tissue reformation limits the gels' ability to provide physical support …

Diffuse white-matter disease associated with small-vessel disease and dementia is
prevalent in the elderly. The biological mechanisms, however, remain elusive. Using …

The therapeutic efficacy of stem cells transplanted into an ischaemic brain depends primarily
on the responses of the neurovascular unit. Here, we report the development and …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …