Background Hepatosteatosis is the earliest stage in the pathogenesis of nonalcoholic fatty
(NAFLD) and alcoholic liver disease (ALD). As NAFLD is affecting 10–24% of the general …

Important protective roles of intestinal alkaline phosphatase (IAP)–including regulation of
intestinal surface pH, absorption of lipids, detoxification of free nucleotides and bacterial …

Metabolic endotoxemia, commonly derived from gut dysbiosis, is a primary cause of chronic
low grade inflammation that underlies many chronic diseases. Here we show that mice fed a …

Over the past few years, there is increasing evidence implicating a novel role for Intestinal
Alkaline Phosphatase (IAP) in mitigating inflammatory mediated disorders. IAP is an …

Intestinal alkaline phosphatase (IAP) plays an essential role in intestinal homeostasis and
health through interactions with the resident microbiota, diet and the gut. IAP's role in the …

The intestinal microbiota plays a pivotal role in maintaining human health and well-being.
Previously, we have shown that mice deficient in the brush-border enzyme intestinal alkaline …

Mice deficient in intestinal alkaline phosphatase (IAP) develop type 2 diabetes mellitus
(T2DM). We hypothesized that a high level of IAP might be protective against T2DM in …

Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …

Intestinal alkaline phosphatase (IAP) regulates bicarbonate secretion, detoxifies
lipopolysaccharide (LPS), regulates gut microbes, and dephosphorylates proinflammatory …

Objective: To determine the role of intestinal alkaline phosphatase (IAP) in enteral starvation-
induced gut barrier dysfunction and to study its therapeutic effect as a supplement to prevent …