Short bowel syndrome (SBS), a condition defined by insufficient absorptive intestinal
epithelium, is a rare disease, with an estimated prevalence up to 0.4 in 10,000 people …

Regenerative medicine (RM) is changing how we think and practice transplant medicine. In
regenerative medicine, the aim is to develop and employ methods to regenerate, restore or …

Cell‐seeded scaffolds play critical roles in the production of tissue engineered intestine
(TEI), a potential strategy for the treatment of short bowel syndrome. The current study …

Functions of the gastrointestinal tract include motility, digestion and absorption of nutrients.
These functions are mediated by several specialized cell types including smooth muscle …

Controlling cellular alignment is critical in engineering intestines with desired structure and
function. Although previous studies have examined the directional alignment of cells on the …

Oriented smooth muscle layers in the intestine contract rhythmically due to the action of
interstitial cells of Cajal (ICC) that serve as pacemakers of the intestine. Disruption of ICC …

Smooth muscle cells (SMCs) are mural cells that play a vital contractile function in many
tissues. Abnormalities in SMC organization are associated with many diseases including …

Although critical for studies of gut motility and intestinal regeneration, the in vitro culture of
intestinal muscularis with peristaltic function remains a significant challenge. Periodic …

The gastrointestinal (GI) tract has a diverse set of physiological functions, including
peristalsis, immune defense, and nutrient absorptions. These functions are mediated by …

Gastroparesis leads to inadequate emptying of the stomach resulting in severe negative
health impacts. Appropriate long-term treatments for these diseases may require pyloric …