Traditional cell lines and xenograft models have been widely recognized and used in
research. As a new research model, organoids have made significant progress and …

While mouse models and two-dimensional (2D) cell culture systems have dominated as
research tools for cancer biology, three-dimensional (3D) cultures have gained traction as a …

Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell
survival and increased immune evasion in breast cancer (BCa). Current in vitro models do …

Background The dismal prognosis of advanced ovarian cancer calls for the development of
novel therapies to improve disease outcome. In this regard, we set out to discover new …

Cell-in-cell (CIC) structures contribute to tumor aggressiveness and poor prognosis in oral
squamous cell carcinoma (OSCC). In vitro 3D models may contribute to the understanding of …

Simple Summary We investigate the use of the small molecule epigenetic modulator 4SC-
202 as a potential cancer therapeutic or adjuvant for Triple Negative Breast Cancer (TNBC) …

Breast cancer has become the highest incidence of cancer in women. It was extensively and
deeply studied by biologists and medical workers worldwide. However, the meaningful …

Cancer-associated fibroblasts (CAFs) are key contributors to ovarian cancer (OC)
progression and therapeutic resistance through dysregulation of the extracellular matrix …

Microglia have an increasingly well-recognised role in the pathogenesis of
neurodegenerative diseases, thereby becoming attractive therapeutic targets. However, the …

In this study, concentrated polymer brush-modified cellulose nanofibers (CNFs) with different
fiber lengths were used for the flocculation of cells for systematically studying the …