Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Obesity and type 2 diabetes are the most frequent metabolic disorders, but their causes
remain largely unclear. Insulin resistance, the common underlying abnormality, results from …

Mitochondria form dynamic networks in the cell that are balanced by the flux of iterative
fusion and fission events of the organelles. It is now appreciated that mitochondrial fission …

Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

The bioactive sphingolipid metabolites ceramide and sphingosine-1-phosphate (S1P) are a
recent addition to the lipids accumulated in obesity and have emerged as important …

The global prevalence of metabolic diseases such as type 2 diabetes mellitus,
steatohepatitis, myocardial infarction, and stroke has increased dramatically over the past …

Ceramides are products of metabolism that accumulate in individuals with obesity or
dyslipidaemia and alter cellular processes in response to fuel surplus. Their actions, when …

BACKGROUND Ceramides are sphingolipids that play causative roles in diabetes and heart
disease, with their serum levels measured clinically as biomarkers of cardiovascular disease …

The activity of 5′-adenosine monophosphate-activated protein kinase (AMPK) is inversely
correlated with the cellular availability of glucose. When glucose levels are low, the …