Background Single-cell genomics techniques are revolutionizing our ability to characterize
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have …

Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia;
however, they cause frequent undesirable side effects. The incidence of statin-induced …

Human leukocyte antigen (HLA)–E belongs, with HLA-G and HLA-F, to the nonclassic major
histocompatibility complex (MHC) class I (Ib) molecules, broadly defined by a limited …

Angiogenesis is increasingly recognized as an important prognosticator associated with the
progression of lymphoma and as an attractive target for novel modalities. We report a …

Until recently, allograft rejection was thought to be mediated primarily by alloreactive T cells.
Consequently, immunosuppressive approaches focused on inhibition of T cell activation …

A better knowledge of the process by which inflammatory extracellular signals are relayed
from the plasma membrane to specific intracellular sites is a key step to understand how …

Anti-HLA Abs have been shown to contribute to the process of transplant vasculopathy by
binding to HLA class I molecules expressed by the endothelial and smooth muscle cells of …

Numerous reports have highlighted the central role of regulatory T cells in long-term allograft
tolerance, but few studies have investigated the B-cell aspect. We analyzed the B-cell …

Among transplant recipients, those who produce antibodies against the donor's human
leukocyte antigens (HLAs) are at higher risk for antibody-mediated rejection and transplant …

Antibody (Ab) crosslinking of HLA I molecules on the surface of endothelial cells triggers
proliferative and pro-survival intracellular signaling, which is implicated in the process of …