Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response
H Wu, AF Malone, EL Donnelly, Y Kirita… - Journal of the …, 2018 - journals.lww.com
Background Single-cell genomics techniques are revolutionizing our ability to characterize
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have …
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have …
Myotoxicity of statins: Mechanism of action
P du Souich, G Roederer, R Dufour - Pharmacology & therapeutics, 2017 - Elsevier
Statins are effective drugs to reduce cardiovascular events secondary to dyslipidemia;
however, they cause frequent undesirable side effects. The incidence of statin-induced …
however, they cause frequent undesirable side effects. The incidence of statin-induced …
Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation
S Coupel, A Moreau, M Hamidou, V Horejsi… - Blood, 2007 - ashpublications.org
Human leukocyte antigen (HLA)–E belongs, with HLA-G and HLA-F, to the nonclassic major
histocompatibility complex (MHC) class I (Ib) molecules, broadly defined by a limited …
histocompatibility complex (MHC) class I (Ib) molecules, broadly defined by a limited …
[HTML][HTML] Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion
X Huang, X Bai, Y Cao, J Wu, M Huang… - The Journal of …, 2010 - ncbi.nlm.nih.gov
Angiogenesis is increasingly recognized as an important prognosticator associated with the
progression of lymphoma and as an attractive target for novel modalities. We report a …
progression of lymphoma and as an attractive target for novel modalities. We report a …
Antibodies in transplantation: the effects of HLA and non-HLA antibody binding and mechanisms of injury
NM Valenzuela, EF Reed - Transplantation Immunology: Methods and …, 2013 - Springer
Until recently, allograft rejection was thought to be mediated primarily by alloreactive T cells.
Consequently, immunosuppressive approaches focused on inhibition of T cell activation …
Consequently, immunosuppressive approaches focused on inhibition of T cell activation …
The adaptor Lnk (SH2B3): an emerging regulator in vascular cells and a link between immune and inflammatory signaling
J Devallière, B Charreau - Biochemical pharmacology, 2011 - Elsevier
A better knowledge of the process by which inflammatory extracellular signals are relayed
from the plasma membrane to specific intracellular sites is a key step to understand how …
from the plasma membrane to specific intracellular sites is a key step to understand how …
HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway
PT Jindra, YP Jin, E Rozengurt… - The Journal of …, 2008 - journals.aai.org
Anti-HLA Abs have been shown to contribute to the process of transplant vasculopathy by
binding to HLA class I molecules expressed by the endothelial and smooth muscle cells of …
binding to HLA class I molecules expressed by the endothelial and smooth muscle cells of …
[HTML][HTML] Long-term allograft tolerance is characterized by the accumulation of B cells exhibiting an inhibited profile
L Le Texier, P Thebault, A Lavault, C Usal… - American journal of …, 2011 - Elsevier
Numerous reports have highlighted the central role of regulatory T cells in long-term allograft
tolerance, but few studies have investigated the B-cell aspect. We analyzed the B-cell …
tolerance, but few studies have investigated the B-cell aspect. We analyzed the B-cell …
HLA Class I Molecules Partner with Integrin β4 to Stimulate Endothelial Cell Proliferation and Migration
X Zhang, E Rozengurt, EF Reed - Science signaling, 2010 - science.org
Among transplant recipients, those who produce antibodies against the donor's human
leukocyte antigens (HLAs) are at higher risk for antibody-mediated rejection and transplant …
leukocyte antigens (HLAs) are at higher risk for antibody-mediated rejection and transplant …
[HTML][HTML] Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus
YP Jin, NM Valenzuela, ME Ziegler, E Rozengurt… - American Journal of …, 2014 - Elsevier
Antibody (Ab) crosslinking of HLA I molecules on the surface of endothelial cells triggers
proliferative and pro-survival intracellular signaling, which is implicated in the process of …
proliferative and pro-survival intracellular signaling, which is implicated in the process of …